The Super Bowl is not just a game; it’s a cultural phenomenon that captures the attention of millions. For companies, it’s an opportunity to showcase their brand on one of the biggest stages in the world. This year, Pfizer is back with another powerful ad that continues its mission to fight cancer and raise awareness about the importance of early detection.
A New Story of Resilience
Pfizer’s 2024 Super Bowl commercial, titled “Knock Out,” features a young cancer patient who is portrayed as a boxing champion. The ad opens with the child shadowboxing, symbolizing his determination and strength in battling the disease. As the commercial progresses, the boy rings a celebratory bell often used to mark the end of cancer treatment, signaling a victory over the illness.
The ad then shows the child running through a crowd of cheering supporters, a nod to the iconic movie “Rocky.” Finally, he reunites with his parents at home, highlighting the emotional journey of overcoming cancer.
The Power of Music
The soundtrack for the commercial is LL Cool J’s 1990 hit song “Mama Said Knock You Out.” This choice was intentional, as the rapper and his wife, Simone Smith, a cancer survivor, are partnering with Pfizer to share their care journey throughout the year and highlight the importance of early detection.
LL Cool J shared his thoughts on the collaboration, saying, “It feels good to have my song used for such an important cause. Strength and resilience are at the heart of hip-hop, and they’re just as crucial in the fight against cancer.”
A Continued Commitment to Cancer Research
This ad marks the second consecutive year that Pfizer is advertising during the Super Bowl. The company has been doubling down on its fight against cancer, with a goal to bring eight cancer breakthrough therapies to market by 2030.
The ad was created in collaboration with Publicis Groupe – Le Truc, Leo NY, Collective, and others. The production was led by Reset, with support from post-production agencies The Den Editorial, BaconX, and Harbor Picture Company.
A Message of Hope and Awareness
The commercial concludes with text underscoring Pfizer’s commitment to cancer research and encouraging viewers to visit PfizerForAll, its direct-to-consumer (DTC) platform. This platform offers valuable resources, including the American Cancer Society’s CancerRisk360 tool and information related to atrial fibrillation.
PfizerForAll, which received almost 10 million pageviews in the final four months of 2024, also features an AI-powered digital platform called Health Answers by Pfizer. This innovation provides patients with personalized responses to health and wellness questions, summarized from trusted independent sources.
A Successful Debut

Last year, Pfizer made its Super Bowl debut with the “Here’s to Science” campaign, which celebrated the 175th anniversary of the company and the legacy of science and medicine. The ad, set to Queen’s “Don’t Stop Me Now,” was a success, leading to a rise in consumer trust of the brand from 49% to 71%.
While some data suggested that the ad was among the lowest-performing during Super Bowl LVIII, other metrics showed that it had 1.6x more engagement than the median ad during that period.
The Future of Oncology
Pfizer’s focus on oncology has grown significantly following the $43 billion acquisition of cancer biotech Seagen in 2023. On the regulatory front, the company anticipates three regulatory decisions in prostate cancer, colorectal cancer, and non-Hodgkin lymphoma, as well as seven Phase 3 readouts and 12 potential pivotal program starts for different types of cancer.
Conclusion
Pfizer’s 2024 Super Bowl commercial is a powerful reminder of the company’s ongoing commitment to fighting cancer and raising awareness about the importance of early detection. With a compelling story, a strong soundtrack, and a message of hope, the ad is sure to resonate with viewers and continue Pfizer’s legacy of innovation and dedication in the field of oncology.
Author: Jane Doe
Title/Role: Senior Healthcare Correspondent
Credentials: With over a decade of experience covering healthcare and pharmaceutical news, Jane has reported on major developments in medical research, drug approvals, and public health initiatives.
Profile Link: www.janedoehealth.com
Internal Links:
– Pfizer’s Role in Cancer Research
– Understanding the Super Bowl Ad Strategy
– The Impact of Digital Platforms on Healthcare
Call to Action: Stay updated with the latest news on healthcare innovations and corporate strategies by following our coverage. Explore today’s headlines and stay informed.
URL Slug: us-trending-news-pfizer-super-bowl-commercial-2024
Image Optimization:
– 
–
– 
–
–
More Stories
US Trending News: The History and Legacy of Zoo York in Streetwear Culture
US Trending News: Exploring Zach Top Greensboro
US Trending News: Youngboy Concert in Birmingham: What to Know Before You Go